Endocrine Abstracts

Introduction: Hormone-secreting teratomas are well described. However teratomas secreting pancreatic hormones are rare, with even fewer cases producing clinically significant effects. We describe possibly the first documented case of hyperinsulinaemic hypoglycaemia due to an insulin-secreting ovarian teratoma.Case report: A 23-year-old woman presented with transient symptoms of lethargy and weakness. She had used her father’s capillary glucose meter...

Introduction: Osteonecrosis is an increasingly common complication in young people treated for acute lymphoblastic leukaemia (ALL). This is likely to be due to the now universal use of high dose steroids.Aim: The aim of this study was to obtain information on prevalence, current UK management and long-term outcomes of patients.Methods: We retrospectively collated data on patients with osteonecrosis for the most recently completed t...

Introduction: HbA1c levels are used as objective long-term measure of glycaemic control in patients with type 1 diabetes mellitus (T1DM). Regular HbA1c measurement helps us to formulate the management and education to the patients and carers. But, in rare cases, it might not prove reliable, as in our case report.Case report: A 4 years old girl with known T1DM and autoimmune hyperthyroidism, had mitral valve repair for mitral valve regurgitation. She was ...

Breast cancer is the most frequent carcinoma in women and its prevalence could be reduced by early detection which can improve the chances of successful treatment and recovery. Post transcriptional genetic modifiers known as microRNAs (miRNAs) are widely believed to play an essential role in many malignancies, acting as either tumor suppressors or oncogenes. Many recent studies on breast cancer have analyzed various miRNAs that may influence breast cancer progression and devel...

A retrospective single centre audit was conducted on the effects of polycythaemia in trans-male and native male.Polycythaemia is a recognised side effect of testosterone treatment. It could be viewed as a maker of excess testosterone action. We examined whether lipid profiles as a marker of cardiovascular risk differed in a population of polycythaemic transmen (TM) and native males (NM).Forty-six NM and 12 TM were identified to hav...

Endocrinopathies are becoming increasingly recognised with the use of new anticancer drugs. Ipilimumab therapy has recently been associated with hypophysitis. The presentation of hypopituitarism can be non-specific and diagnosis in an oncology setting may be challenging. We describe a 77-year-old man who presented to oncology with a short history of lethargy, nausea, anorexia, and weight loss. He had completed four cycles of ipilimumab as treatment for melanoma 7–9 months...

Background: Hyperthyroidism often runs an indolent course and may be undiagnosed for prolonged periods. Most patients are treated in the outpatient setting and the effects of hyperthyroidism on hospitalised patients are poorly studied. We set out to determine the prevalence of hyperthyroidism in a large cohort of inpatients and evaluated their comorbidities, reasons for hospitalisation and rehospitalisation rates.Methods: A case-control study was conduct...

: Recent Phase 3 studies have demonstrated the clinical utility of immunotherapy with inhibitors of PD1 in cancers, including melanoma and non-small cell lung cancer. Autoimmune side effects are common. Both hypothyroidism and hyperthyroidism have been observed in up to 16% of patients. We report for the first time the endocrine evaluation of patients with anti-PD1 induced thyroid dysfunction.Methods: All patients treated in published trials of anti-PD1 ...

Introduction: Prader–Willi syndrome (PWS) is a genetic syndrome usually diagnosed in childhood. Its reported prevalence ranges from one in 8000 to one in 45 000 with geographical variation. Clinical manifestations include obesity, hyperphagia, short stature, incomplete sexual development, and cognitive disabilities. The majority of published data regarding PWS comes from paediatric populations.Materials and methods: This is a retrospective observati...

Diabetic polyneuropathy is the most prevalent complication of diabetes. Diabetic foot lesions become limb threatening from a combination of injury, infection and impaired micro and macrocirculation. When diabetic patients go on holiday they usually change their routine and may become careless in routine care of their feet. We report a case series of seven middle aged Irish born diabetic male patients who developed serious foot lesion on holiday. They were identified from the p...